个人简介：

郝继娜，副教授，硕士生导师。2017年博士毕业于同济大学化学科学与工程公司，师从闫冰教授。博士毕业后进入bevictor伟德李永生教授课题组开展博士后研究，于2020年7月出站留校工作，先后任职特聘副研究员、副教授至今。致力于稀土杂化荧光探针的导向构筑及其疾病早期诊断性能研究。迄今发表 SCI 论文近 40 篇，全部论文 SCI 他引总计 2500 余 次，H 指数 25，以第一或通讯作者在 Chem. Soc. Rev., Adv. Mater., Angew. Chem. Int. Ed., Adv. Funct. Mater. 等期刊发表 SCI 论文 25 篇，单篇最高引用 330 余次；获授权国家发明专利 3 项；入选上海市青年科技启明星计划以及上海市青年科技英才扬帆计划。

研究方向：

荧光杂化探针的导向设计、构筑及应用性能研究，主要包括：

• 稀土光功能晶态杂化体系的组装及其荧光传感性能研究

• 金属-有机骨架（MOFs）复合材料的构筑及应用

承担项目：

1. 国家自然科学基金面上项目，主持，2026.01-2029.12

2. 国家重点研发计划子课题，主持，2024.12-2029.11

3. 国家自然科学基金面上项目，主持，2022.01-2025.12

4. 国家自然科学基金青年基金，主持，2019.01-2021.12

5. 上海市青年科技启明星计划，主持，2021.07-2024.06

6. 上海市自然科学基金面上项目，主持，2021.07-2024.06

7. 上海市青年英才扬帆计划，主持，2018.05-2021.04

代表性论文：

1. Guoli Chen, Bin Dai, Ji-Na Hao*, Yongsheng Li*, A dual-excitation-driven full-component- responsive lanthanide-based metal-organic framework for switchable profiling of multi-Disease markers, Sci. China Mater., 2025, 68, 666.

2. Xing Yao, Wen Li, Ji-Na Hao*, Yongsheng Li*, Controllable construction of imine-linked covalent organic frameworks with regular morphologies by a stepwise feeding-engineered uniform polymerization strategy, Appl. Mater. Today, 2025, 46, 102863.

3. Guoli Chen, Ji-Na Hao*, Yongsheng Li*, Sensitive and fast assessment of DNA methylation degree by a luminescent lanthanide-functionalized MOF probe, Microchem. J., 2025, 215, 114469.

4. Kaiming Ge, Guoli Chen, Dapeng Zhang, Ji-Na Hao*, Yongsheng Li*, Leap-Type Response of Redox/Photo-Active Lanthanide-Based Metal-Organic Frameworks for Early and Accurate Screening of Prostate Cancer, Angew. Chem. Int. Ed., 2024, 63, e202411956. 

5. Tao Hu, Ji-Na Hao*, Yongsheng Li*, A highly luminescent lanthanide-functionalized covalent organic framework for rapid and specic detection of 7-methylguanine for DNA methylation assessment, Biomater. Sci., 2024, 12, 5266.

6. Ji-Na Hao, Kaiming Ge, Guoli Chen, Bin Dai, Yongsheng Li*, Strategies to engineer various nanocarrier-based hybrid catalysts for enhanced chemodynamic cancer therapy, Chem. Soc. Rev., 2023, 52, 7707.

7. Xianglong Li, Cong Jiang, Xinlin Jia, Yuanyuan Cao, Yuanqing Mao, Ji-Na Hao*, Yang Yang, Peng Zhang,* Yongsheng Li*, Dual “Unlocking” Strategy to Overcome Inefficient Nanomedicine Delivery and Tumor Hypoxia for Enhanced Photodynamic-Immunotherapy, Adv. Healthcare Mater. 2023, 12, 2202467. 

8. Xianglong Li, Cong Jiang, Qinghua Wang, Shaobo Yang, Yuanyuan Cao, Ji-Na Hao*, Dechao Niu, Yan Chen, Bo Han, Xin Jia, Peng Zhang*, Yongsheng Li*, A “valve-closing” starvation strategy for amplification of tumor-specific chemotherapy, Adv. Sci., 2022, 9, 2104671.

9. Ji-Na Hao, Dechao Niu, Jinlou Gu, Shaoliang Lin*, Yongsheng Li*, Jianlin Shi, Structure Engineering of a Lanthanide-Based Metal-Organic Framework for the Regulation of Dynamic Ranges and Sensitivities for Pheochromocytoma Diagnosis, Adv. Mater., 2020, 32, 2000791.

10. Yufang Shu, Ji-Na Hao*, Dechao Niu*, Yongsheng Li, A smart luminescent metal-organic framework-based logic system for simultaneous analysis of copper ions and hydrogen sulfide, J. Mater. Chem. C, 2020, 8, 8635.

11. Ji-Na Hao, Yongsheng Li*, Concurrent Modulation of Competitive Mechanisms to Design Stimuli-Responsive Ln-MOFs: A Light-Operated Dual-Mode Assay for Oxidative DNA Damage, Adv. Funct. Mater., 2019, 29, 1903058.

12. Ji-Na Hao, Xiaoyu Xu, Honghan Fei*, Liangchun Li*, Bing Yan*, Functionalization of metal-organic frameworks for photoactive materials, Adv. Mater., 2018, 30, 1705634.

13. Ji-Na Hao, Bing Yan*, Determination of urinary 1-hydroxypyrene for biomonitoring of human exposure to polycyclic aromatic hydrocarbons carcinogens by a lanthanide-functionalized metal-organic framework sensor, Adv. Funct. Mater., 2017, 27, 1603856.

课题组网站：https://mesolab.ecust.edu.cn/